Change in leukocyte telomere length predicts mortality in patients with stable coronary heart disease from the heart and soul study

Peer-Reviewed Scientific Journal:

Size of study:
608 adults with stable coronary artery disease

In this study, 608 individuals with CAD were followed over time and measured for leukocyte telomere length at the beginning and end of 5 years.  Mortality occurred in 39% of patients who experienced telomere shortening, 22% of patients with stable telomere length, and 12% of patients who experienced telomere lengthening. As compared with patients whose telomere length was maintained, those who experienced telomere lengthening were 56% less likely to die at the end of 5 years. This study showed that an increase in leukocyte telomere length over 5 years is associated with decreased mortality.

Link to study


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