Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency

Peer-Reviewed Scientific Journal:
Journal of Clinical Investigation

Size of study:
Mouse model

Summary
Mice with a genetic mutation for a form of cardiovascular disease that causes premature calcification of the aortic valve (CAV) in addition to longer telomeres, did not develop disease. In contrast, mice with this mutation but short telomeres, did develop CAV and the severity of the disease progression tracked the degree of telomeric shortening.

Link to study

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4 comments on “Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency

    • Hi Dean – Thank you for your inquiry. We are not quite sure which “expensive chemical” you are referring to and therefore are unable to respond appropriately. Best, TeloYears

    • Hi Terri – Thank you for your interest. We are not aware of any studies that look at HGH (Human Growth Hormone, we assume) and telomere length. Best, TeloYears

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