Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States

Peer-Reviewed Scientific Journal:

Size of study:
10,568 participants with a mean age of 44.1 years

The researchers assessed estimated glomerular filtration rate (eGFR) and urinary albumin excretion using urinary albumin-creatinine ratio (ACR), as well as telomere length using qPCR, the proprietary assay used by TeloYears, of 10,568 participants from the NHANES cohort. After analysis, they found that eGFR significantly decreased and ACR significantly increased across increasing quarters of telomere length.  The study’s authors concluded that the association of kidney disease markers with a well established proxy of cellular senescence, telomere length, suggests underlying mechanisms behind the progression of nephropathy.

Link to study


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