Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysian Older Adults

Peer-Reviewed Scientific Journal:
Current Gerontology and Geriatrics Research

Size of study:
300 adults aged 60+

Summary
This study aimed to identify neuroprotective factors for cognitive decline in different ageing groups using biomarkers associated with cognitive fitness – telomere length, vitamin D levels and BDNF (brain-derived neurotrophic factor). The 300 study participants were categorized into three groups: mild cognitive impairment (MCI), usual ageing (UA), and successful ageing (SA) and all participants were measured for the above mentioned biomarkers. Data analysis showed that that the reduction of the risk of MCI was achieved by higher serum vitamin D level, higher plasma BDNF level, and longer telomere length. In conclusion, participants with higher vitamin D level, higher BDNF level, and longer telomere length were more likely to age successfully and stave off the risk of age-induced cognitive decline.

Link to study

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