Peer-Reviewed Scientific Journal:
The Lancet Oncology
Size of study:
35 men; 10 with prostate cancer and 25 controls
After previously finding an association between 3 months of comprehensive lifestyle changes and increased telomerase activity in human immune-system cells, the authors followed up participants to investigate long-term effects (ten men and 25 external controls who had biopsy-proven low-risk prostate cancer and had chosen to undergo active surveillance). Men in the intervention group followed a programme of comprehensive lifestyle changes (diet, activity, stress management, and social support), and the men in the control group underwent active surveillance alone. Relative telomere length increased from baseline by a median of 0•06 telomere to single-copy gene ratio (T/S) units (IQR –0•05 to 0•11) in the lifestyle intervention group, but decreased in the control group (–0•03 T/S units, –0•05 to 0•03, difference p=0•03). When data from the two groups were combined, adherence to lifestyle changes was significantly associated with relative telomere length after adjustment for age and the length of follow-up (for each percentage point increase in lifestyle adherence score, T/S units increased by 0•07, p=0•005).