Peer-Reviewed Scientific Journal:
Size of study:
88 subjects, 44 with mood disorders, 44 age matched controls
Our data show a significant telomere shortening in PBMC from AD versus controls (P=0.04).Telomere length of T cells, correlated with AD disease status, measured by Mini Mental Status Exam (MMSE) scores (P=0.025). T cell telomere length also inversely correlated with serum levels of the proinflammatory cytokine TNFalpha (a clinical marker of disease status), with the proportion of CD8+ T cells lacking expression of the CD28 costimulatory molecule, and with apoptosis. These findings suggest an immune involvement in AD pathogenesis.