Telomere end-replication problem and cell aging

Telomeres » Institutional Study » Telomere end-replication problem and cell aging

March 30, 2017 | Amy | Leave a comment

Peer-Reviewed Scientific Journal:
Journal of Molecular Biology

Size of study:
In vitro modelling

Summary
Read this hallmark paper on the end-replication problem published in 1992 and co-authored by TeloYears Chief Scientific Officer, Calvin Harley. In this paper he and other authors that include Carol Greider, who won the 2009 Nobel Prize for Medicine and Physiology in her work on telomere biology, describe how telomere attrition can be attributed to the end-replication process and how this results in cellular senescence.

Link to study

SEE THE FULL STUDY

Leave a Reply Cancel reply

The TeloYears test is not intended for screening, diagnosing, treating or preventing diseases or medical conditions. The TeloYears genetic test may indicate the possibility of identifying a rare telomere syndrome associated with extremely shorter or longer average telomere length (ATL). In these rare cases, further testing and consultation with a doctor to rule in or rule out a telomere syndrome is recommended. The test is available for individuals between the ages of 20 to 80 within the United States, except for the states of Maryland and New York. The information provided by the TeloYears test should not be used to replace medically appropriate screening tests recommended based upon actual age or other risk factors, nor should the information be used to make decisions about diagnosis or treatment of diseases or medical conditions. The Telomere Diagnostics lab is regulated under the Clinical Laboratory improvement Amendments of 1988 (CLIA) as qualified to perform high complexity clinical testing. The performance characteristics of this test were determined by Telomere Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration.